Critical Shortage of New RSV Shot Puts Infants with Chronic Lung Disease at Risk

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New York City, October 25, 2023

In a concerning development, the availability of a groundbreaking RSV (respiratory syncytial virus) shot for infants has dwindled, leaving U.S. health officials with the challenging task of prioritizing its distribution to the most vulnerable babies. The Centers for Disease Control and Prevention (CDC) has issued a crucial advisory urging doctors to ensure that infants under six months, particularly those with chronic lung disease or other underlying health conditions, are given precedence for this lifesaving treatment.

RSV, a viral pathogen responsible for cold-like symptoms, poses a significant threat to the health of young children, making this shortage a cause for concern. The virus is currently surging across the southern United States, with experts predicting continued transmission over the coming weeks.

The innovative one-time shot, known by the brand name Beyfortus, is a laboratory-developed antibody designed to bolster a baby’s immune system in its fight against RSV. This groundbreaking medication is the result of collaboration between pharmaceutical giants AstraZeneca and Sanofi.

The U.S. Food and Drug Administration granted approval for Beyfortus in July, followed by a recommendation from the CDC the following month. The CDC’s guidance is particularly aimed at infants born just before or during the RSV season, as well as those under eight months of age when the season commences. Furthermore, a single dose is recommended for certain high-risk infants aged 8 to 19 months. Beyfortus is available in prefilled syringes, offered in either 50-milligram or 100-milligram doses, with the latter being reserved for larger, heavier infants.

Recent correspondence to state immunization managers from the CDC informed them of a temporary suspension on orders for these shots under the program that supports vaccines for low-income and uninsured children. In response to the growing concerns, the CDC released a broader advisory to healthcare providers across the United States.

In a statement, Sanofi acknowledged that the demand for Beyfortus, especially the larger doses, has exceeded their initial projections. Unfortunately, the current supply is insufficient to protect all eligible infants, even those in need of the larger doses. Furthermore, a scarcity of the smaller doses may be experienced during the ongoing RSV season. The CDC emphasized that using two smaller doses on larger infants is not a viable solution and could further strain the already limited supply.

In light of this critical shortage, some children may still qualify for an older RSV drug called palivizumab, which necessitates monthly injections. Health officials are also strongly encouraging doctors to engage expectant mothers in discussions about a new vaccine specifically designed to safeguard newborns from RSV. By immunizing pregnant women, the need for administering the antibody drug to their babies can be significantly reduced.

The shortage of RSV shots for infants has raised serious concerns, especially for the most vulnerable members of the population. The ongoing efforts of healthcare providers and pharmaceutical companies are essential in mitigating this crisis and ensuring that every child in need receives the protection they deserve. The situation remains fluid, and authorities are working diligently to address the supply issue and protect our youngest and most vulnerable citizens from the perils of RSV.

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